IndraLab

Statements

TP53 inhibits USP22. 4 / 4
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"The upregulation of TP53 inhibited the upregulation of USP22."
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"To further validate the effect of p53 on USP22 expression, we depleted p53 in RKO and HCT116 cells, and found USP22 was increased by p53 depletion at both protein and mRNA levels (Fig. 4C, D)."
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"Our study demonstrates that p53 represses USP22-mediated stabilization of FASN, thus provides an alternative pathway connecting p53 and fatty acid synthesis."
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"In HCC cells with wild-type TP53 , p53 blocks the HIF-1α-induced upregulation of USP22."
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