IndraLab

Statements

FN1 binds NRP1. 14 / 14
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"Indeed, we observe that NRP-1 co-distributes with α5β1 and mutation of S612 in NRP-1 markedly impairs FN fibril assembly and disrupts FN binding with NRP-1."
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"First, to assess FN binding with NRP-1, b-FN was precipitated from LX2 cell lysates collected from RFP and NRP-1 overexpressing cells incubated with b-FN and loaded into SDS-PAGE for Western blot analysis of NRP-1 and b-FN."
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"NRP-1 binds with FN."
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"NRP-1 achieves this function through complementary utilization of extracellular and intracellular protein domains that allow binding between FN and NRP-1 and activation of the nonreceptor tyrosine kinase c-Abl."
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"Indeed, we observe that NRP-1 co-distributes with alpha5beta1 and mutation of S612 in NRP-1 markedly impairs FN fibril assembly and disrupts FN binding with NRP-1."
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"In addition, we found that ginsenoside Rg3 can block the interaction of NRP1 and FN1 and inhibit the progression of gastric cancer."
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"Surprisingly, rescue of fibronectin binding following Nrp1 knockdown was only seen using vectors carrying full-length Nrp but not Nrp constructs lacking the C-terminal PDZ-binding motif, suggesting coupling between integrin and PDZ-domain proteins."
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"The NRP1 extracellular domain is O linked glycosylated via the serine 612 residue, which increases NRP1 binding to fibronectin resulting in enhanced fibronectin and alpha5beta1 integrin interaction."
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"Our study suggested that the interaction of NRP1 and FN1 is crucial for the malignant progression of gastric cancer."
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"NRP1 induces integrin function by binding to fibronectin and by activating the intracellular kinase c-Abl."
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"Since prior studies have indicated that NRP-1 can transduce intracellular signals by binding with GIPC ( xref ), we also investigated the role of GIPC in FN fibril assembly by NRP-1."
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"NRP-1 binds with FN."
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"Our study suggested that the interaction of NRP1 and FN1 is crucial for the malignant progression of gastric cancer."
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"In addition, we found that ginsenoside Rg3 can block the interaction of NRP1 and FN1 and inhibit the progression of gastric cancer."
33116644