IndraLab

Statements

MAP3K7 activates CYLD. 6 / 6
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"These data collectively suggest that sustained Tak1 activation in Itch -/- and Cyld -/- BMDMs results in chronic production of proinflammatory cytokines."
22057290
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"Tak1 activation in Itch -/- and Cyld -/- BMDMs."
22057290
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"27 Of note, deregulated Tak1 ubiquitination also contributes to the hyperactivation of NF-kappaB and JNK in CYLD deficient T cells, 26 suggesting that Tak1 is a common target of CYLD in the innate and adaptive immune responses."
19373246
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"Furthermore, consistent with the constitutive Tak1 activation in Cyld -/- T cells, transfected CYLD potently suppressed the catalytic activity of Tak1 (XREF_FIG)."
17548520
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"In mature T cells, CYLD targets TAK1 for inactivation to downregulate IKK and NF-kappaB activation [XREF_BIBR]."
21119682
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"To determine whether Tak1 is a functional target of CYLD, we analyzed the effect of CYLD on Tak1 ubiquitination."
17548520