IndraLab

Statements

USP9X deubiquitinates IRS2. 6 / 6
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"Thus, it is possible that USP9X preferentially deubiquitinates IRS-2 much more than IRS-1 because of the difference of such ubiquitination patterns."
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"IRS-2 deubiquitination by USP9X maintains anchorage independent cell growth via Erk1/2 activation in prostate carcinoma cell line."
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"Knockdown of USP9X dramatically reduced IRS-2 protein level, increased IRS-2 ubiquitination, and promoted the proteasomal degradation of IRS-2 in PC3 cells, suggesting that USP9X also deubiquitinates IRS-2 to prevent its proteasomal degradation."
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"These data suggest that USP9X deubiquitinates IRS-2 and prevents its proteasomal degradation."
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"In addition, USP9X in LNCaP cells was not co-immunoprecipitated with IRS-2 (XREF_SUPPLEMENTARY), suggesting that USP9X does not deubiquitinate IRS-2 in LNCaP cells."
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"In addition, the interaction between USP9X and IRS-2 was not observed in LNCaP cells (XREF_SUPPLEMENTARY), suggesting that USP9X in LNCaP does not deubiquitinate and stabilize IRS-2 because of the absence of interaction between them."
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