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"Compared to saline, tegaserod significantly inhibited AWR in group H (0.4 mL : from 2.0 to 0.5; 0.8 mL : from 3.5 to 1.5; 1.2 mL : from 4.0 to 3.0, P < 0.01), but had no significant effect on group C. Tegaserod dose-dependently attenuated the number of c-Fos positive neurons in limbic structures, anterior cingulate cortex (ACC) showed the greatest attenuation."