IndraLab

Statements

OTUD7B inhibits conjugation. 4 / 4
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"Instead, in the absence of Cezanne, HA K11-linked ubiquitin (an HA-tagged ubiquitin K11 mutant in which all of the lysine residues except lysine 11 are mutated to arginine) conjugation increased, consistent with a role of Cezanne DUB activity in antagonizing K11-conjugation on damaged chromatin (Fig. 4C; Paul and Wang 2017)."
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"This is consistent with our previous finding that Cezanne antagonizes RNF8 and Ube2S-dependent K11-conjugation on damaged chromatin (Paul and Wang 2017)."
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"Since it has been shown that Cezanne K11-DUB activity not only functions toward K11-chains but also extends to K11-linkage within K11/K63- and K11/Lys48-branched chains (Mevissen et al. 2016), it is likely that at least one of the functions of Cezanne is to prevent K11-conjugation on K63-chains forming mixed K63/K11-chains to protect the “purity” of K63-chains."
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"Cezanne deficiency increases K11-ubiquitin conjugation but does not affect K63- conjugation at DNA damage sites."
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