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2-methoxy-17beta-estradiol inhibits USP13. 2 / 2

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"As shown in Figure 7 D, we detected that 2-methoxyestradiol significantly inhibited USP13-mediated cleavage of K63-Ub4 ( Figure 7 D)."

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"Then, we used K63-linked tetra-Ub (K63-Ub4) as substrate to further confirm whether 2-methoxyestradiol could inhibit catalytic activity of USP13 toward K63-linked polyubiquitination."

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IndraLab

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2-methoxy-17beta-estradiol inhibits USP13. 2 / 2

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