IndraLab

Statements

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"The intervention using Vialinin A and liver X receptor α (LXRα)-induced cannabinoid receptor 2 (CB2) has been found to reduce the level of USP4, leading to alleviate inflammation and fibrosis in the liver (74)."
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"We next elucidated the function of USP4 in the microglia activation-induced inflammation."
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"In a model of autoimmune hepatitis in mice, the expression of USP4 was found to be reduced upon treatment with Vi-A, thereby reducing inflammation and fibrosis in the liver [31]."
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"Here the downregulation of USP4 promotes microglial activation and subsequent neuronal inflammation through attenuating the deubiquitination of K63 linked TRAF6 and reversing its suppressor role in the NF-kappaB signaling pathway."
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"In experimental animal, there were increases in inflammation and fibrosis as well as USP4, and which were reduced after treatment of Vialinin A. Vialinin A also reduced Rheb and phosphorylated mTOR."
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"Notably, the cessation of USP4 induces microglial activation and subsequent inflammation through NF-κB in secondary spinal cord injury."
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