IndraLab

Statements

DLG1 binds KCNA3. 4 / 7
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"Interestingly, Dlg1 interacts with the Kv1.3 through the PDZ binding domain ( xref )."
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"Therefore, it is still possible that the Dlgh1–Kv1.3 interaction is relevant for Dlgh1-mediated NFAT activation in naive T cells."
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"By contrast, Dlgh1 can bind to the voltage-gated potassium channel Kv1.3 [10] , which is important to enable sustained Ca 2+ mobilization and, thus, to sustain NFAT activation in naive but not effecto[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In addition, we show in vivo association of hDlg with Kv1.3 channel, which was expressed in T lymphocytes as an epitope-tagged protein using a vaccinia virus expression system."
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