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"NLRP3 inflammasomes have been regulated by STAMBP, a deubiquitinase STAM-binding protein identified by Joseph S et al. [125] upon contact with Toll-like receptor agonists or bacterial lipopolysaccharide (LPS), STAMBP knockdown by CRISPR/Cas9 gene editing increase the expression of many cytokines and chemokines [126]."