IndraLab

Statements

TNFAIP3 inhibits Neoplasms. 7 / 7
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"On one hand, TNFAIP3 can reduce the progression of inflammation‐related tumors."
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"Loss of A20 expression also leads to malignancies , especially B cell lymphomas ."
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"Importantly, KO of TNFAIP3 inhibited tumor growth promoted by both mutant H-Ras and FGFR1 activation, suggesting that TNFAIP3 may serve as a potential target for inhibiting ER- breast cancer with active mutant Ras and/or active FGFR1 signaling."
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"Consistent results were also observed in the xenograft tumor growth assay in mice, where activation of the iFGFR1 signaling markedly enhanced tumor growth and KO of TNFAIP3 inhibited tumor growth derived from DCIS-iFGFR1 cells."
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"Moreover, absence of Kmt2d affects negatively the expression of major B-cell tumor suppressors such as Tnfaip3, Socs3, Tnfrsf14, Asxl1 or Arid1a."
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"In addition, the knockdown of YTHDF2 and EPHB3 or the knockdown of YTHDF2 and TNFAIP3 promoted the tumor growth in xenograft model under TMZ treatment compared with YTHDF2 silence alone (Supplementary figure 3j)."
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"In vivo experiments showed that TNFAIP3 expression in DLBCL was downregulated, and upregulation of TNFAIP3 could inhibit tumor growth."
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