IndraLab

Statements

TNFAIP3 inhibits Neoplasms. 4 / 4
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"Loss of A20 expression also leads to malignancies , especially B cell lymphomas ."
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"Moreover, absence of Kmt2d affects negatively the expression of major B-cell tumor suppressors such as Tnfaip3, Socs3, Tnfrsf14, Asxl1 or Arid1a."
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"Consistent results were also observed in the xenograft tumor growth assay in mice, where activation of the iFGFR1 signaling markedly enhanced tumor growth and KO of TNFAIP3 inhibited tumor growth derived from DCIS-iFGFR1 cells."
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"Importantly, KO of TNFAIP3 inhibited tumor growth promoted by both mutant H-Ras and FGFR1 activation, suggesting that TNFAIP3 may serve as a potential target for inhibiting ER- breast cancer with active mutant Ras and/or active FGFR1 signaling."
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