IndraLab

Statements

SP1 inhibits USP22. 3 / 4
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eidos
"In summary , our results demonstrate that USP22 expression is promoted by AP2 and c-Myc and is suppressed by SP1 and ATF3 at the transcriptional level ."
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"To demonstrate the upregulation of USP22 by USP7 knockdown is associated with desuppression of SP1 transcriptional activity, USP7 was knocked down, 24 h later, control plasmid and SP1 plasmids were individually introduced to overexpress SP1 in H1299 cells, additional 48 h later, proteins were extracted, Western blot analysis showed that reintroduction of SP1 significantly attenuated the upregulation of USP22 by USP7 knockdown (Fig. 2D)."
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"In contrast, knockdown of Sp1 enhanced USP22 promoter activity and mRNA levels."
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