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OTUD4 activates TGFB. 5 / 5
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"OTUD4 enhances TGFbeta signalling through regulation of the TGFbeta receptor complex ."
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"Previously, OTUD4 was reported to regulate the TGFβ receptor complex and enhance TGFβ signaling, which could stimulate tumor cells to undergo EMT and promote CSC invasion and metastasis [ 26–29 ]."
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"Specifically , we find that OTUD4 enhances TGFbeta signalling by promoting the membrane presence of TGFbeta receptor I. Furthermore , we demonstrate that OTUD4 inactivates the TGFbeta negative regulator SMURF2 suggesting that OTUD4 regulates multiple nodes of the TGFbeta pathway to enhance TGFbeta activity ."
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"OTUD4 enhances TGFbeta signalling through regulation of the TGFbeta receptor complex."
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"OTUD4 in the TGF-β signalling pathway enhances overall TGF-β activity through a positive feedback loop."
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