IndraLab

Statements

UCHL1 activates MITF. 3 / 3
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"UCH-L1 contributes to melanoma development by decreasing the stability of MITF as well as regulating the PI3K/Akt signaling pathway (64)."
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"In addition, UCH-L1 increases the ubiquitination and degradation of microphthalmia-related transcription factor (MITF) by binding to ubiquitinated MITF (64)."
36844618
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"These results indicated that UCHL1 negatively influenced the stability of MITF protein.We next investigated the potential molecular mechanism underlying the observed downregulation of MITF protein ind[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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