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MALAT1 inhibits USP8. 4 / 4
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"Moreover, MALAT1 inhibits ubiquitin-proteasomal degradation of the N-HER2 by affecting the binding of deubiquitinase USP8 and N-HER2, thereby promoting N-HER2 accumulation and trastuzumab resistance in HER2-positive breast cancer."
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"In this study, we showed that MALAT1, through the direct interaction with PTBP1, promoted the degradation of USP8 mRNA and inhibited USP8-mediated regulation of TAK1 protein.As an RNA-binding protein and a splicing factor, PTBP1 may activate or repress the transcription of a target gene, by regulating pre-mRNA splicing, polyadenylation, mRNA stability, and/or translation initiation [31]."
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"Up-regulation of METTL3 increases the expression level of MALAT1 through m6A methylation modification to promote the degradation of USP8 mRNA, thereby regulating the ubiquitination and protein stability of TAK1, and promoting macrophage pyroptosis and inflammation (23)."
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"METTL3 increased MALAT1 levels through m A methylation to downregulate USP8; the reduced USP8 decreased TAK1 ubiquitination and degradation, which promoted macrophage pyroptosis and inflammation."
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