IndraLab

Statements

Phenethyl caffeate inhibits RELA. 14 / 18
4 | 1 11 2
reach
"In summary, these results demonstrate that in ECs, CAPE abolishes the transcriptional activity of the zebrafish ortholog p65, and therefore it can be used to temporally block p65 activity within the embryonic developing vascular cord."
39242546
reach
"To confirm the inhibition of p65 by CAPE in zebrafish embryos, we performed cleavage under targets and release using nuclease qPCR (CUT&RUN-qPCR) for p65 at 22hpf in 16-22hpf CAPE-treated zebrafish embryos, or DMSO controls."
39242546
reach
"Pretreatment with CAPE specifically decreased the content of NF-κB p65 in nuclei, then induced the down-regulation of release of TNF-α and NO, significantly protected the liver against radiation-induce[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25704035
reach
"IF staining revealed that CAPE inhibited p65 to enter the nucleus of 109-T15 and 9706-T15 cells compared to the cells with DMSO treatment."
29650964
reach
"However, CAPE and CAPE-pNO 2 significantly increased 1.4- and 1.5-fold in cytoplasm p65 expression and decreased 0.8- and 0.7-fold in nuclear p65; as well as p-IkappaBalpha was 0.7- and 0.7-fold and TGF-beta1was 0.6- and 0.3-fold at 20 muMu, compared with the HG induced GMCs, which had similar effects to those of caused by 100 muM PDTC treatment."
29383098
reach
"The inhibitor of NF-κB p65 activity, caffeic acid phenethyl ester (CAPE) (cat."
36551169
reach
"In LPS-induced murine macrophages, CAPE prevented NF-κB-induced p65 from binding to DNA sites but not IκB degradation ( Choi et al., 2015 )."
27832944
sparser
"IF staining revealed that CAPE inhibited p65 to enter the nucleus of 109- T15 and 9706- T15 cells compared to the cells with DMSO treatment (Fig.  xref , lower)."
29650964
reach
"Thus, CAPE may inhibit the p65-dependent activation of NF-κB.CAPE occurs naturally in propolis."
31118570
sparser
"IF staining revealed that CAPE inhibited p65 to enter the nucleus of 109- T15 and 9706- T15 cells compared to the cells with DMSO treatment (Fig.  xref , lower)."
29650964
reach
"We further examined whether CAPE-induced inhibition of NFκB transactivation is responsible for downregulation of PLD1 and found that CAPE attenuated NFκB (p65)-dependent transcriptional activation of [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24103753
reach
"Moreover, CAPE inhibits the p65 subunit of NF-κB from moving to the nucleus, but it has no discernible effect on the TNF-α-induced degradation of IκBα."
39296435
eidos
"Caffeic acid phenethyl ester can down-regulate TLR4 , MyD88 , IRAK4 , TRIF and NF-kappaB p65 expression , induce cell apoptosis , and induce autophagy during the process in LPS-induced breast cancer cells [ 108 ] ."
30213077
reach
"Our animal study also revealed that CAPE treatment reduced protein abundance of NF-kappaB p65 in PC-3 tumors."
27191743