IndraLab

Statements

CYLD activates DDX58. 5 / 5
| 2 3
eidos
"The effect of CYLD was not specific to RIG-I , as CYLD also deubiquitinated and inhibited the signaling activities of TBK1 and IKKepsilon ."
25023063
eidos
"Ubiquitylation events are reversible processes , and , accordingly , severaldeubiquitylating enzymes , in particular ubiquitin specific peptidase 3 ( USP3 ) , USP21 and CYLD lysine 63 deubiquitinase ( CYLD ) , modulate RIG-I signalling by removing K63-polyubiquitin chains , although with unique kinetics ( reviewed elsewhere112 ,118 ) ."
31792373
reach
"The data indicate that CYLD targets RIG-I as well as TBK1 for deubiquitination that leads to inactivation of the signaling."
18703349
reach
"miR-526a downregulates the expression of the deubiquitylating enzyme CYLD, which ultimately promotes RIG-I K63 linked ubiquitylation and interferon responses 152."
31792373
reach
"Ubiquitylation events are reversible processes, and, accordingly, several deubiquitylating enzymes, in particular ubiquitin specific peptidase 3 (USP3), USP21 and CYLD lysine 63 deubiquitinase (CYLD), modulate RIG-I signalling by removing K63-polyubiquitin chains, although with unique kinetics."
31792373