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USP18 inhibits IFNAR2. 2 / 4

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"In addition to its isopeptidase activity, USP18 negatively regulates type I and type III IFN signalling by blocking the IFNAR2 subunit of the interferon receptor ."

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"In addition, independent of its enzymatic activity, USP18 can inhibit the type 1 interferon (IFN-1) signal transduction by binding the Interferon-alpha/beta receptor (IFNAR2) [18]."

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USP18 inhibits IFNAR2. 2 / 4

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