IndraLab

Statements

Ubiquitin activates USP7. 6 / 6
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"Binding of Ub triggers a drastic conformational change in the active site of HAUSP that realigns the catalytic triad for specific catalysis on the C-terminal di-glycine motif of Ub 36."
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"Hao-Fountain syndrome (HAFOUS) is a rare neurodevelopmental disorder caused by mutations in the ubiquitin-specific protease 7 (USP7) gene for endosomal recycling."
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"TP53 Ub-ID lead to low number but consistent identifications (Fig. 9c): PCNA, BCOR, RNF20, RNF40, RNF220, RFC4, the Ub E1 activating enzyme UBA1 and the deubiquitylating enzyme USP7."
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"It shows that ubiquitin trapped in the active site of USP7 causes rearrangements of the catalytic triad and the adjacent " switching " loop of USP7."
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"Natively, USP7 exists in an inactive state and is activated by the binding of ubiquitin to an allosteric site within its catalytic domain."
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"Taking these data together, USP7 beta represents a higher MW species of USP7 that shares significant amino acid homology.ICP0 can catalyse the ubiquitination of USP7 (Boutell et al., 2005), suggesting[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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