IndraLab

Statements

USP7 inhibits FOXO4. 4 / 4
| 4
reach
"However, in contrast to the stimulating activity of MATH-33, USP7 negatively regulates FOXO1 and FOXO4 [42,43] ."
29704981
reach
"USP7 reverses this monoubiquitylation, and thereby restricts FOXO1 and FOXO4-dependent transcriptional responses."
29704981
reach
"For example, the deubiquitylase MATH-33 recently has been reported to stabilize and activate DAF-16 by antagonizing polyubiquitylation, while its mammalian counterpart USP7 and HAUSP inhibits FOXO1 and FOXO4 by decreasing their nuclear localization and transcriptional activity, respectively, by removing monoubiquitin moieties [XREF_BIBR - XREF_BIBR]."
28562327
reach
"Consequently, USP7 expression inhibited FOXO4 transcriptional activity due to de-ubiquitination of FOXO4 and re-localization to the cytosol."
18665269