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USP7 inhibits FOXO4. 2 / 2

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"Consequently, USP7 expression inhibited FOXO4 transcriptional activity due to de-ubiquitination of FOXO4 and re-localization to the cytosol."

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"For example, the deubiquitylase MATH-33 recently has been reported to stabilize and activate DAF-16 by antagonizing polyubiquitylation, while its mammalian counterpart USP7 and HAUSP inhibits FOXO1 and FOXO4 by decreasing their nuclear localization and transcriptional activity, respectively, by removing monoubiquitin moieties [XREF_BIBR - XREF_BIBR]."

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USP7 inhibits FOXO4. 2 / 2

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