IndraLab

Statements

Disopyramide inhibits KCNH2. 5 / 9
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"Meanwhile, disopyramide was demonstrated to block I hERG1 at clinically relevant concentrations (IC 50 < 10 muM), and this action was proposed to constitute the molecular basis of its proarrhythmic effect."
21833176
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"Stereoselective block of the hERG potassium channel by the Class Ia antiarrhythmic drug disopyramide."
39607488
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"In this regard, disopyramide inhibition of hERG appears similar to the drug's open-channel inhibition of Kv1.5, which depends on drug–channel interaction with the S6 helix but for which residues at th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21989164
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"Considered collectively, therefore, our mutagenesis and docking data support a scheme in which disopyramide inhibition of hERG occurs via inner cavity interactions with F656 and Y652 on channel openin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21989164
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"Recently, McPate et al. suggested that hERG block by the class I antiarrhythmic disopyramide is only slightly attenuated by the N588K mutation, suggesting that it may be worth investigating disopyramide as a clinical adjunct for SQT1 [90]."
17298291