IndraLab

Statements

USP22 activates FBP1. 3 / 3
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"Moreover, it has been shown that USP22 promotes cell growth by regulating the far upstream element (FUSE)-binding protein 1 (FBP1), a transcriptional regulator of p21 [XREF_BIBR]."
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"Hence USP22 silencing reduces the capacity of FBP1 to repress p21 (independently of TP53 status), which in turn inhibits CDKs to prevent the G1/S transition and resulting in G1 accumulation [XREF_BIBR]."
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"Our results showed that USP22 silencing downregulated COX-2 and FBP1 in A549 and NCI-H460 cells compared to control siRNA."
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