IndraLab

Statements

USP15 inhibits mitophagy. 6 / 6
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"Thus , USP15 knockdown enhanced mitophagy but only in the presence of Parkin ."
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"Interestingly , USP15 strongly inhibited Parkin-mediated mitophagy , while the other DUBs had no effect ( Fig. 1A and B ) ."
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"As demonstrated above in HeLa cells ( Fig. 2A ) , USP15 knockdown does not enhance mitophagy in the complete absence of Parkin ."
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"Overexpression of USP15 inhibits mitophagy dependently of its catalytic activity , while depletion of USP15 enhances mitophagy ."
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"USP15 knockdown rescues the mitophagy defect of PARK2 mutant PD patient fibroblasts As demonstrated above in HeLa cells ( Fig. 2A ) , USP15 knockdown does not enhance mitophagy in the complete absence of Parkin ."
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"USP15 , a deubiquitinase specifically counteracts the parkin-mediated ubiquitination of mitochondria and thus prevents mitophagy , while USP15 knockdown stimulates mitochondrial ubiquitination and age-dependent mitophagy defects in Parkin-deficient muscles and dopaminergic neurons [ 91,106 ] ."
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