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E3_Ub_ligase activates USP1. 2 / 2

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"USP1 is targeted for proteasomal degradation by the multi-subunit E3 ligase, APC/C Cdh1 in a cell cycle dependent manner [XREF_BIBR], so perhaps the decrease in USP1 is a consequence of the ability of PEITC to cause cell cycle arrest [XREF_BIBR, XREF_BIBR]."

28881649

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reach

"USP1 dependency is driven by RAD18, an E3 ubiquitin ligase that catalyzes PCNA monoubiquitination, and UBE2K, a novel regulator of PCNA polyubiquitination."

36228090

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IndraLab

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E3_Ub_ligase activates USP1. 2 / 2

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