IndraLab

Statements

GW 7647 inhibits USP1. 5 / 5
| 5
reach
"Pimozide and GW7647 inactivate USP1 and UAF1 in cells."
22118673
reach
"Pimozide and GW7647 inhibit USP1 and UAF1 by a noncompetitive mechanism."
22118673
reach
"In order to demonstrate that pimozide and GW7647 inhibit the USP1 and UAF1 activity in cells, we developed an assay to determine the levels of Ub-PCNA or Ub-FANCD2 in cells treated with cisplatin, pimozide and GW7647 or a combination of cisplatin and pimozide and GW7647."
22118673
reach
"Although two inhibitors namely pimozide and GW7647 were reported to selectively inhibit USP1 and UAF1, they also inhibited other DUBs, deSUMOlyase and cysteine proteases [XREF_BIBR]."
25481052
reach
"Further studies of the USP1/UAF1 inhibitors suggested that pimozide and GW7647 inhibit USP1/UAF1 by a non‐competitive mechanism and bind at a site other than the active site of USP1/UAF1 [113]."
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