IndraLab

Statements

GW 7647 inhibits USP1. 5 / 5
| 5
reach
"In order to demonstrate that pimozide and GW7647 inhibit the USP1 and UAF1 activity in cells, we developed an assay to determine the levels of Ub-PCNA or Ub-FANCD2 in cells treated with cisplatin, pimozide and GW7647 or a combination of cisplatin and pimozide and GW7647."
22118673
reach
"Further studies of the USP1/UAF1 inhibitors suggested that pimozide and GW7647 inhibit USP1/UAF1 by a non‐competitive mechanism and bind at a site other than the active site of USP1/UAF1 [113]."
24239534
reach
"Although two inhibitors namely pimozide and GW7647 were reported to selectively inhibit USP1 and UAF1, they also inhibited other DUBs, deSUMOlyase and cysteine proteases [XREF_BIBR]."
25481052
reach
"Pimozide and GW7647 inhibit USP1 and UAF1 by a noncompetitive mechanism."
22118673
reach
"Pimozide and GW7647 inactivate USP1 and UAF1 in cells."
22118673