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"The KCNH2 and KCNQ1 mutations are associated with different ion channel dysfunctions, xref , xref and gene specific triggers of arrhythmias. xref In LQT-1, it is recognized that exercise (catecholamine) is the primary trigger because of the malfunctioning I Ks channels that leads to less effective shortening of the QT intervals during tachycardia than in normal individuals."