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"The anti-inflammatory agent, ibuprofen, has been shown to inhibit constitutive activation of NF-kappaB and IKKalpha in prostate cancer cells (Palayoor et al, 1999), and when combined with megestrol acetate produced an increase in body weight in gastrointestinal cancer patients (McMillan et al, 1999), while megestrol acetate alone produced a decrease in body weight."

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"The anti-inflammatory agent ibuprofen inhibited the constitutive activation of NF-kappaB and IKKalpha in PC-3 and DU-145 cells, and blocked stimulated activation of NF-kappaB in LNCaP cells."

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"Ibuprofen has been shown to inhibit the constitutive activation of IKKalpha and NF-kappaB in androgen independent prostate tumor cells XREF_BIBR."