IndraLab

Statements

OTUD3 inhibits PTEN. 3 / 3
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"In breast cancer, OTUD3 suppresses tumorigenesis and progression by stabilizing PTEN [46]."
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"OTUD3 loss of function increases the Ub-dependent degradation of PTEN and enhances PI3K/AKT signaling in breast cancer cells ( Yuan et al., 2015 )."
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"In addition to regulating GRP78 to promote tumorigenesis in NSCLC, OTUD3 suppressed tumorigenesis in breast, colon, liver, brain, esophageal, and cervical cancer by stabilizing PTEN, ZFP36 or p53 [23–25]."
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