IndraLab

Statements

KCNH2 activates sodium(1+). 3 / 3
| 3
reach
"Moreover, the KCNH2 potassium channels may directly regulate the characteristics of sodium and calcium channels XREF_BIBR."
23613831
reach
"In this way, hERG inactivation allows sodium and calcium conductances to maintain ventricular depolarization for more than a whopping 300 ms (compared to <3 ms for a neuronal action potential)."
31669064
reach
"Reduced I leads to prolonged APD and QT interval.47LQT2: Loss-of-function mutations in KCNH2 reduce I , another critical repolarizing current that activates rapidly and helps terminate the action potential.38 48LQT3: Gain-of-function mutations in SCN5A increase the late sodium current (I ), leading to a persistent I during the plateau phase, prolonging APD and QT interval.49Understanding these mechanisms provides insight into the pathophysiology of LQTS and guides the development of targeted therapies and risk stratification strategies."
39263612