IndraLab

Statements



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"YTHDF1 can promote gastric carcinogenesis via Wnt receptor frizzled7 (FZD7) and USP14 [17], and its loss in gastric tumors restores sensitivity to antitumor immunity by recruiting mature dendritic cells [19]."

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"Furthermore, USP14 has been reported to enhance antiviral immune response by increasing the stability of CXCR4, releasing more IL-6 and TNF-α cytokines [117], and accelerating MHC-I antigen presentation [122]."

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"Herpes simplex virus (HSV-1) induces TRIM14 expression and recruits the deubiquitinating enzyme USP14, which inhibits the K48 linked polyubiquitination of cGAS to increase its stability and enhances the immune response against HSV-1."