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SP1 inhibits USP13. 5 / 5
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"We also showed that USP13 directly removes classical K48-linked ubiquitin chains from the Raf1 protein ( xref G ), while inhibition of USP13 by Sp-1 promotes mESC self-renewal in an autophagy-independent manner ( xref )."
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"Sp-1 simultaneously inhibits the activity of USP10 and USP13 (19)."
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"Because USP13 is a deubiquitinated protein, we hypothesized that Sp-1 will accelerate the degradation of target proteins by inhibiting USP13."
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"We also showed that USP13 directly removes classical K48-linked ubiquitin chains from the Raf1 protein (Fig. 6G), while inhibition of USP13 by Sp-1 promotes mESC self-renewal in an autophagy-independent manner (Fig. S4)."
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"Moreover, Sp-1 functions by inhibiting the activity of USP10 and USP13, while PD0325901 is a specific inhibitor of MEK (5, 19)."
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