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Statements

CYLD decreases the amount of SERPINE1. 11 / 11
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"In this study, we provided evidence to show that CYLD inhibits PAI-1 expression probably through directly interacting with and deubiquitinating TRAF-6."
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"CYLD knockdown by using siRNA- CYLD increased PAI-1 mRNA expression in WT MEF cells, whereas overexpression of WT CYLD attenuated PAI-1 mRNA expression in Cyld −/− MEF cells ( Figure S5 A)."
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"Our evidences here demonstrated that CYLD inhibited S. p -stimulated PAI-1 expression."
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"Pneumolysin (a virulence factor produced by S pneumonia) induces CYLD expression, which inhibits the expression of plasminogen activator inhibitor-1 (PAI-1) in the lung, they report, and CYLD deficiency protects mice against pneumolysin induced lung injury."
| PMC
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"Results from the same study using the CYLD knockout cells have showed that CYLD negatively regulates PAI-1 expression via inhibition of MKK3-p38 MAPK signaling pathway [18]."
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"Our data demonstrate that CYLD, highly induced by S. pneumoniae , negatively regulates MKK3-p38 MAPK-dependent PAI-1 expression in lung, which in turn leads to enhanced ALI, severe hemorrhage, and inc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Based on these information, we propose that CYLD associates, deubiquinites and in-activates TRAF-6, thus inhibiting subsequent PAI-1 expression."
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"CYLD was suggested to interfere with the NFAT signalling pathway by deubiquitylating transforming growth factor-β-activated kinase 1 (TAK1), and to negatively regulate KK3-p38 kinase-dependent expression of plasminogen activator inhibitor-1 [39], [40]."
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"Furthermore, CYLD contributes to the worsening of ALI by suppressing the expression of plasminogen activator inhibitor 1 (PAI-1), a recognized biomarker of tissue injury that plays a crucial role in tissue repair (36, 46)."
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"The authors showed that CYLD inhibited S. p -induced PAI-1 expression in lung, thereby potentiating pulmonary damages [18]."
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"We demonstrated that CYLD, highly induced by PLY, negatively regulated MKK3-p38 kinase-dependent expression of plasminogen activator inhibitor-1 (PAI-1) in lung, which in turn led to potentiation of l[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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