IndraLab

Statements

CYLD decreases the amount of SERPINE1. 10 / 10
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"CYLD was suggested to interfere with the NFAT signalling pathway by deubiquitylating transforming growth factor-β-activated kinase 1 (TAK1), and to negatively regulate KK3-p38 kinase-dependent expression of plasminogen activator inhibitor-1 [39], [40]."
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"In this study, we provided evidence to show that CYLD inhibits PAI-1 expression probably through directly interacting with and deubiquitinating TRAF-6."
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"In this issue of Immunity, Lim et al. (2007) demonstrate that CYLD, a deubiquinating enzyme, represses the expression of plasminogen activator inhibitor-1, which is critical in preventing tissue damage."
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"Cylindromatosis (CYLD) inhibits Streptococcus pneumonia induced plasminogen activator inhibitor-1 expression via interacting with TRAF-6."
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"Our evidences here demonstrated that CYLD inhibited S. p -stimulated PAI-1 expression."
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"Together, these results indicate that TRAF-6 mediates S.p-induced PAI-1 expression, and CYLD inhibits PAI-1 expression probably through deubiquitinating TRAF-6."
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"Pneumolysin (a virulence factor produced by S pneumonia) induces CYLD expression, which inhibits the expression of plasminogen activator inhibitor-1 (PAI-1) in the lung, they report, and CYLD deficiency protects mice against pneumolysin induced lung injury."
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"The authors showed that CYLD inhibited S. p -induced PAI-1 expression in lung, thereby potentiating pulmonary damages [18]."
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"Results from the same study using the CYLD knockout cells have showed that CYLD negatively regulates PAI-1 expression via inhibition of MKK3-p38 MAPK signaling pathway [18]."
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"Based on these information, we propose that CYLD associates, deubiquinites and in-activates TRAF-6, thus inhibiting subsequent PAI-1 expression."
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