IndraLab

Statements

OTUB1 leads to the deubiquitination of CCN6. 4 / 4
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"Consistently, we found that OTUB1 could not remove the already synthesized K48 ubiquitin chains on CCN6 in the in vitro deubiquitination assay (Figure S9), indicating that OTUB1 reduces the ubiquitination of CCN6 independent of its canonical activity."
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"However, the D88A mutant lacking non‐canonical function could not reduce the ubiquitination of CCN6, suggesting that OTUB1 inhibits the ubiquitination of CCN6 in a non‐canonical way."
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"Furthermore, OTUB1 inhibited the ubiquitination of CCN6 in a non-canonical manner."
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"Further study showed OTUB1 interacts with CCN6 and decreases CCN6 ubiquitination independent of its enzymatic activity (Zhao et al., 2023)."
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