IndraLab

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Nitric oxide inhibits MAPK8. 14 / 17
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"23 NO donors can inhibit JNK1 via S nitrosylation at Cys116, leading to reduced JNK1 phosphorylation."
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"NO can inhibit JNK1 via S-nitrosylation at C116 , leading to reduction of Bcl2 phosphorylation , which ultimately increases its interaction with Beclin1 ."
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"Furthermore, NO does not induce MCL-1 protein degradation in the absence of Jnk1."
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"Moreover, Sarkar et al. [XREF_BIBR] demonstrated that nitric oxide (NO), in contrast to ROS, inhibited JNK1 by S nitrosylation and subsequently suppressed autophagy in rat primary neurons."
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"We previously showed that NO negatively regulates JNK1 by a thiol redox mechanism [58]."
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"These data suggest that NO inhibits all three isoforms of JNKs (JNK1, JNK2, and JNK3) through a thiol redox mechanism."
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"Collectively, our data suggest that endogenous NO mediates the IFN-gamma-induced suppression of JNK1 activation in macrophage cells by means of a thiol-redox mechanism."
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"Recently, Sarkar et al. [XREF_BIBR] demonstrated that NO could inhibit autophagy by S nitrosylating and thus inhibiting the activities of IKKbeta and JNK1, potent inducers of autophagy."
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"Moreover, Sarkar et al. [XREF_BIBR] demonstrated that nitric oxide (NO), in contrast to ROS, inhibited JNK1 by S nitrosylation and subsequently suppressed autophagy in rat primary neurons."
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"In addition, NO has been reported to inhibit JNK1 activation in murine microglial cells and macrophages via S -nitrosation of cysteine 116 (Park et al., 2000)."
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"NO can inhibit JNK1 via S nitrosylation at C116, leading to reduction of Bcl2 phosphorylation, which ultimately increases its interaction with Beclin1."
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"JNK1 activity is suppressed after nitrosylation on its Cys116 by nitric oxide generated after IFN- administration in macrophages 38."
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"NO donors can inhibit JNK1 via S nitrosylation at C116, leading to reduced JNK1 phosphorylation."
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"These observations are supported by the results of Western blot showing significantly decreased p-JNK2 levels and a strong tendency to decreased p-JNK1 in cells treated with ionomycin and the NO donor."
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