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Nitric oxide inhibits MAPK8. 22 / 25
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"Recently, Sarkar et al. [XREF_BIBR] demonstrated that NO could inhibit autophagy by S nitrosylating and thus inhibiting the activities of IKKbeta and JNK1, potent inducers of autophagy."
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"Moreover, the NO donor, S-nitroso-N-acetyl-dl-penicillamine (SNAP), was also able to suppress the activation of JNK1 in vivo [155]."
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"These data suggest that NO inhibits all three isoforms of JNKs (JNK1, JNK2, and JNK3) through a thiol redox mechanism."
17054907
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"We previously showed that NO negatively regulates JNK1 by a thiol redox mechanism [58]."
17054907
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"Furthermore, NO does not induce MCL-1 protein degradation in the absence of Jnk1."
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"JNK inhibition of the compound 1n could be block the phosphorylation of c-Jun and repress the activity of c-Jun.The compound 1n showed excellent NO Inhibition activity in LPS-induced BV-2 cell lines w[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The l -arginine-mediated repression of JNK1 activation was restored completely by the addition of DTT, suggesting that the NO generated by nNOS suppresses JNK1 via a thiol-redox mechanism ( Fig. 4 A)."
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"NO donors can inhibit JNK1 via S nitrosylation at C116, leading to reduced JNK1 phosphorylation."
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"23 NO donors can inhibit JNK1 via S nitrosylation at Cys116, leading to reduced JNK1 phosphorylation."
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"In addition, NO has been reported to inhibit JNK1 activation in murine microglial cells and macrophages via S -nitrosation of cysteine 116 (Park et al., 2000)."
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"These observations are supported by the results of Western blot showing significantly decreased p-JNK2 levels and a strong tendency to decreased p-JNK1 in cells treated with ionomycin and the NO donor."
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"Conversely, Sarkar et al. (2011) demonstrated that nitric oxide (NO) inhibited JNK1 and in that way blocked Bcl-2 phosphorylation and stabilized the Bcl-2/Beclin 1 complex inhibiting autophagy."
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"Conversely, Sarkar et al. (2011) demonstrated that nitric oxide (NO) inhibited JNK1 and in that way blocked Bcl-2 phosphorylation and stabilized the Bcl-2/Beclin 1 complex inhibiting autophagy."
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"NO generation was induced in the cells ectopically overexpressing nNOS via the addition of l -arginine to the culture medium, and the NO generated by the nNOS was demonstrated to repress JNK1 specific[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Moreover, Sarkar et al. [XREF_BIBR] demonstrated that nitric oxide (NO), in contrast to ROS, inhibited JNK1 by S nitrosylation and subsequently suppressed autophagy in rat primary neurons."
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"JNK1 activity is suppressed after nitrosylation on its Cys116 by nitric oxide generated after IFN- administration in macrophages 38."
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"According to a recent study of Sarkar, NO can inhibit JNK1 (c-Jun N-Terminal Protein Kinase1) and IKK (I Kappa-B Kinase) via mTOR (mammalian target of rapamycin) and mTOR-independent pathways, respectively, to prevent autophagy."
39840143
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"NO can inhibit JNK1 via S-nitrosylation at C116 , leading to reduction of Bcl2 phosphorylation , which ultimately increases its interaction with Beclin1 ."
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"NO can inhibit JNK1 via S nitrosylation at C116, leading to reduction of Bcl2 phosphorylation, which ultimately increases its interaction with Beclin1."
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"Collectively, our data suggest that endogenous NO mediates the IFN-gamma-induced suppression of JNK1 activation in macrophage cells by means of a thiol-redox mechanism."
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"Conversely, Sarkar et al. (2011) demonstrated that nitric oxide (NO) inhibited JNK1 and in that way blocked Bcl-2 phosphorylation and stabilized the Bcl-2/Beclin 1 complex inhibiting autophagy."
23220384
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"Moreover, Sarkar et al. [XREF_BIBR] demonstrated that nitric oxide (NO), in contrast to ROS, inhibited JNK1 by S nitrosylation and subsequently suppressed autophagy in rat primary neurons."
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