IndraLab

Statements


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"In worms, the activation of the slo-1 BK channel by ethanol is a primary mechanism of the initial sensitivity to the intoxicating effects of ethanol, and loss of slo-1 causes resistance to ethanol."

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"BK channel activators are being explored to counteract hyperexcitability during withdrawal or reduce alcohol-induced euphoria."

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"Altogether, our data demonstrate that BK channel inhibition can modulate alcohol drinking in mice, but the underlying mechanism does not involve the interaction of ethanol with BK α residue K361."

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"Mutations in the Slo gene reduce EtOH-induced sedation and impaired locomotion, suggesting a direct link between BK channel function and motor control."

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"RNAi of the additional positive controls, rab-3 and slo-1, reduced ethanol sensitivity as has been shown for loss-of-function mutants of these genes."