IndraLab

Statements

Lansoprazole inhibits KCNH2. 4 / 4
| 4
reach
"This finding is in agreement with recent evidence showing that lansoprazole in combination with ceftriaxone carries a risk of QTc interval prolongation, as it has been demonstrated that ceftriaxone + lansoprazole can significantly block the hERG channel and inhibit I (− 57.6%) [35, 36]."
33834380
reach
"In the laboratory, we found that, in combination, lansoprazole and ceftriaxone block the hERG channel up to 57.6%, corresponding with an APD70 increase of 50 ms. At these higher lansoprazole concentrations, it is likely that, if treated as a single entity, the combination would not have received regulatory approval."
27737742
reach
"Notably, it has been demonstrated that also lansoprazole alone significantly inhibits hERG potassium channel and related current IKr (-14%), although to a lesser extent when compared to the drug combination (-58%)."
29731714
reach
"In combination, ceftriaxone and lansoprazole block the hERG channel."
27737742