IndraLab

Statements

Lansoprazole inhibits KCNH2. 3 / 3
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"In combination, ceftriaxone and lansoprazole block the hERG channel."
27737742
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"In the laboratory, we found that, in combination, lansoprazole and ceftriaxone block the hERG channel up to 57.6%, corresponding with an APD70 increase of 50 ms. At these higher lansoprazole concentrations, it is likely that, if treated as a single entity, the combination would not have received regulatory approval."
27737742
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"Notably, it has been demonstrated that also lansoprazole alone significantly inhibits hERG potassium channel and related current IKr (-14%), although to a lesser extent when compared to the drug combination (-58%)."
29731714