IndraLab

Statements


Tubulin inhibits CYLD. 2 / 2
| 2

reach
"This interaction inhibits HDAC6 mediated tubulin deacetylation, allowing CYLD to translocate to the perinuclear region."

reach
"This hypothesis is supported by the observation that inhibition of tubulin deacetylation by downregulation of HDAC6 or inhibition of its activity by TSA induced a similar translocation of CYLD to the perinuclear area where it colocalized with the abundant acetylated MTs, whereas depolymerisation of MTs inhibited the translocation."