IndraLab

Statements



reach
"Moreover, IRD targeted pyruvate kinase isozyme type M2 (PKM2) and suppressed its downstream p-JAK1, p-STAT1, p-STAT3, p-p65, iNOS, and COX2, which could be abolished by PKM2 agonist DASA-58 and antioxidant N-acetyl-L-cysteine, but partly be reversed by NF-kappaB activator CUT129 and JAK1 activator RO8191."

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"For example, STAT-1 activated by the transition metal V 2 O 5 is blocked by anti-oxidants N-acetyl-L-cysteine or catalase [XREF_BIBR]."

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"The antioxidant N-acetyl-L-cysteine reduced ROS production and STAT1 activity induced by AngII, indicating that AngII uses ROS as a second messenger to regulate STAT1 activity."