IndraLab

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"In good agreement, DC-specific ablation of OTUD7b induced apoptosis of DCs, prevented the induction of pathogenic CD8 T cells and completely protected from ECM."
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"As shown in Fig. 5 C, PI3K/AKT blockage significantly abolished the effect of Cezanne in DOX-induced apoptosis and autophagy as confirmed by Western blot, which showed that in the DOX + Av-Cezanne + H[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"This study represents one of several reports showing both negative and positive effects of OTUD7B on tumor cell invasiveness 18, 23, 42, 63, a tumorigenic phenotype which we have not addressed here.We further observed one of the major outcomes associated with the stabilization of p53 via enforced OTUD7B expression involved inducing HCC cell apoptosis, phenocopying the p53 response to cellular insults such as unresolved levels of DNA damage."
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"And consistent with OTUD7B-induced apoptosis mainly proceeding through the mitochondrial-dependent pathway, cytochrome c (CYCS) release from mitochondria to the cytoplasm was evident in cells following the overexpression of OTUD7B (Figure 7E)."
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"This illustrates a conserved function of OTUD7b for the prevention of TNF-induced apoptosis in human and murine DCs."
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"OTUD7B promotes apoptosis of hepatocellular carcinoma cells through p53."
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"OTUD7B knockdown inhibits cell proliferation and induces apoptosis in PC3 cells."
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"The deubiquitinating enzyme OTUD7b protects dendritic cells from TNF-induced apoptosis by stabilizing the E3 ligase TRAF2."
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"These findings lead us to suggest that the role of OTUD7B in prostate cancer cells may be linked to autophagy through the modulation of the mTOR signaling pathway.Collectively, our current study demonstrated that OTUD7B knockdown inhibits autophagy through activating AKT/mTOR pathway and positively contributes to the extrinsic apoptosis and proliferation of prostate cancer cell."
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"Moreover, previous research reported that OTUD7B promotes apoptosis in liver cancer cells by negatively regulating NF-κB 24."
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"Moreover, consistent with the idea that OTUD7B promotes apoptosis, the overexpression of OTUD7B resulted in higher levels of cleaved PARP1 and caspase-3 relative to control conditions (Figure 7D)."
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"These results show that OTUD7B downregulation greatly inhibits cell proliferation and promotes apoptosis in PC3 cells."
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"Other phenotypic features consistent with apoptosis observed upon overexpressing OTUD7B in HCC cells were the condensation and fragmentation of nuclear chromatin 49 as detected by flow cytometry and confocal microscopy, respectively (Figure 7F-G), while examination of cleaved caspase 3 staining in HCC xenografts showed that OTUD7B overexpression also increased HCC cell apoptosis rates in vivo (Figure 7H)."
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