IndraLab

Statements

UCHL1 decreases the amount of APP. 4 / 7
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"Mature APP level was reduced by UCHL1 as expected (p < 0.05) (XREF_FIG), and was further reduced by ubiquitin expression (p < 0.01) (XREF_FIG)."
25466238
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"This study suggests that potentiation of UCHL1 might be able to reduce the level of BACE1 and Abeta in brain, which makes it a novel target for AD drug development."
22212137
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"Overexpressing Uch-L1 reduces BACE1 activity and Abeta levels, whereas Uch-L1 null mice exhibit increased number of Abeta plaques and neurofibrillary tangles, thus displaying an inverse relationship with Uch-L1 levels."
26858599
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"To investigate whether UCHL1 reduced APP protein level by the lysosomal degradation, Haw cells were transfected with UCHL1 and then treated with 100muM chloroquine (XREF_FIG)."
25466238