IndraLab

Statements

SORT1 binds KCNK2. 7 / 7
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reach
"This would lead to the internalization of the TREK-1 and Sortilin complex in early endosome and subsequently to its degradation."
20405001
sparser
"The association of TREK-1 with the sorting protein sortilin prompted us to investigate the behavior of mice deleted from the gene encoding sortilin ( Sort1 −/− )."
30127743
sparser
"From the fact that NT and PE are able to bind matured sortilin, the existence of the complex between sortilin and TREK-1 prompted us to test both peptides on the channel activity."
30670975
reach
"In physiological conditions (XREF_FIG), TREK-1 and NTSR3 and Sortilin would associate in the TGN vesicle, where spadin is hydrolyzed by furin."
20405001
sparser
"Interestingly, sortilin physically interacts with the two pore domain potassium channel TREK-1 and the PE as well as its synthetic analog spadin is able to block the activation of TREK-1 highlighting their role in the depression pathology."
30670975
reach
"This interaction between TREK-1 and NTSR3 and Sortilin led us to examine whether NT and/or the partial NTSR3 and Sortilin propeptide (i.e. spadin) were able to act on TREK-1 channel activity."
20405001
sparser
"Since one of the major functions of sortilin is to address numerous proteins from intracellular compartments to the plasma membrane or lysosomes ( xref ; xref ), the question was “Are sortilin and TREK-1 physically associated ?” and, if yes “ Is sortilin involved in the sorting of TREK-1 ?” In this way, we have demonstrated using cross immuno-precipitation that a protein complex existed between sortilin and TREK-1, both endogenously co-localized in same neurons ( xref )."
30670975