IndraLab

Statements


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"The results showed that GA inhibited p65 luciferase activity (by 14.2%, 28.8%, or 57.7%) stimulated with TGFbeta1+ TNFalpha, in a concentration dependent manner."

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"Select GA treatment inhibits activated p65."

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"XREF_BIBR Epigallocatechin-3-gallate (EGCG), a gallic acid ester of catechin, blocks the production of TNF-alpha, IFN-gamma, NF-kB, and p65, which reduces inflammation in the intestinal mucous membrane."

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"However, addition of GA after CDDP treatment could reverse this increase of p65 and p50 in the nucleus."

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"As shown in XREF_FIG, neither PS341 nor various doses of GA consistently decreased the nuclear presence of the NF-kappaB p65 subunit in SU-DHL-2 cells."

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"Although the model used here does not replicate the dementia in human AD, the ability of GA to inhibit activated NF-kappaB p65 and suppress gliosis and inflammatory cytokines suggests potential therapeutic benefits for AD (XREF_FIG)."