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OTUD7B activates autophagy. 15 / 16
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"Overall, our results suggest that OTUD7B knockdown reduces autophagy by activating AKT/mTOR signaling in PC3 cells."
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"Cezanne promoted autophagy through PIK3C3 stabilization and PIK3C2A transcription in lung adenocarcinoma."
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"OTUD7B knockdown inhibits proliferation and autophagy through AKT/mTOR signaling pathway in human prostate cancer cell."
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"As Cezanne could activate cell autophagy, in our study, in low- and high-Cezanne expression cells, we compared the EGFR recycling speed by focusing on the EGFR location in cells."
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"The results showed that under Rapamycin stimulation, PIK3C3 or PIK3C2A knockdown reversed the autophagy activation induced by Cezanne, and the knockdown of both would be more remarkable (Fig. 6E, F)."
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"Third, Cezanne was reported to regulate the stability of p62 [44], so in this study, we did not show the results of p62.In conclusion, this study showed a new network connecting Cezanne, autophagy, and Osimertinib resistance, and in consideration of the wide effect and complexity of autophagy, further study is needed to explore the effect of autophagy induced by Cezanne on other cellular functions."
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"OTUD7B knockdown inhibited autophagy through AKT/mTOR signaling."
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"To identify the underlying mechanism, we speculated that OTUD7B knockdown inhibits autophagy via the AKT/mTOR signaling pathway in PCa cells."
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"Taken together, OTUD7B promotes the proliferation, and autophagy, and inhibits apoptosis of prostate cancer cells via the AKT/mTOR signaling pathway."
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"As shown in Fig. 5 C, PI3K/AKT blockage significantly abolished the effect of Cezanne in DOX-induced apoptosis and autophagy as confirmed by Western blot, which showed that in the DOX + Av-Cezanne + H[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These results indicated that Cezanne might promote autophagy at the autophagosome formation stage.The mRFP-GFP-LC3 was used to show the number of autophagosomes and the autophagosome maturation."
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"These findings lead us to suggest that the role of OTUD7B in prostate cancer cells may be linked to autophagy through the modulation of the mTOR signaling pathway.Collectively, our current study demonstrated that OTUD7B knockdown inhibits autophagy through activating AKT/mTOR pathway and positively contributes to the extrinsic apoptosis and proliferation of prostate cancer cell."
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"OTUD7B knockdown inhibits autophagy in prostate cancer cells via the AKT/mTOR signaling pathway."
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"As shown in Fig. 6A–D, the GST-tag fluorescence intensity is greater and the quantity is more in Cezanne OE cells, suggesting more production of PI3P in Cezanne OE cells.To further illustrate the effect of PIK3C3 and PIK3C2A on autophagy activation promoted by Cezanne, we used siRNA to knock down PIK3C3 and PIK3C2A."
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"Cezanne was shown to activate cell autophagy, making us wonder whether Cezanne could promote Osimertinib resistance in an autophagy-dependent way.To validate this hypothesis, we treated PC9 and HCC827 cells with 50 ng/ml EGF and captured the distribution of EGFR and an early-endosome marker, Rab5, at 5 and 15 min using confocal microscopy."
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