IndraLab

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"LPS-induced TBK1 activation and the expression of cytokines, including IFN-β, RANTES and CXCL-10 were decreased in macrophages after GC treatment; however, poly(dA:dT)-induced TBK1 activation and cyto[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Notably, H-151 (Figure 1) is a novel selective inhibitor of STING that has been demonstrated to irreversibly reduce type I interferon response, inhibit TBK1 phosphorylation, and inhibit STING Cys91 palmitoylation, thereby suppressing downstream signaling activation [12], thereby suppressing downstream signal activation.The aim of this study was to investigate the activation of the STING–TBK1 pathway in lipopolysaccharide-induced AKI and the protective effects of H-151 in inhibiting the activation of STING–TBK1 and its impact on renal function.3."
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"On the other hand, LPS treatment down-regulated IRF3, TBK1 and TRIF in 4F treated MDMs compared to vehicle pre-treatment."
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"Our data revealed that CYT387 treatment with LPS repressed the production of IFNβ, confirming our previous findings that CYT387 is a potential inhibitor of Tbk1 ( Fig. 3 A )."
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