IndraLab

Statements

Probucol inhibits KCNH2. 9 / 11
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"Arsenic trioxide and probucol were reported to accelerate hERG protein degradation from the cell membrane (2, 23)."
39386239
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"Probucol also disrupted hERG trafficking and did not block hERG channels expressed in human embryonic kidney 293 cells."
17377062
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"Probucol impairs trafficking of hERG and K 7.1 (voltage-gated K -channel 7.1), responsible for the rapid and slow component of the delayed-rectifier potassium current (I an I ), respectively, thus creating a link to the occurrence of QT prolongation and arrhythmias (Taniguchi et al., 2012)."
37492082
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"XREF_BIBR By decreasing hERG channel-membrane density, probucol can cause LQTS and torsades de pointes arrhythmia in patients and sudden cardiac death in experimental animals."
26229434
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"Our data demonstrate that probucol accelerated the degradation of mature hERG channels, which associated with caveolin-1 (Cav1) in hERG expressing HEK cells."
21278233
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"Probucol induced hERG channel reduction can be rescued by matrine and oxymatrine in vitro."
31657676
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"Therefore, we speculate that maybe LDL cholesterol could also protect QTc interval from prolongation in schizophrenia patients treated with antipsychotics just through such a similar mechanism as preventing probucol-induced reduction of the hERG current."
34483996
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"XREF_BIBR, XREF_BIBR Our data show that probucol (30, 50, and 100 muM) treatment decreases the mature 155 kDa band of hERG, but does not reduce the intracellular forms of the immature hERG 135 kDa band (XREF_FIG), suggesting that probucol may not block hERG forward trafficking."
26229434
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"For example, the antiarrhythmic agents ketoconazole and fluoxetine have been shown to reduce hERG density by at least 50% following 48 hours of treatment, XREF_BIBR - XREF_BIBR whereas pentamidine and probucol reduce cell-surface hERG without affecting ion conduction."
20156596