IndraLab

Statements

USP38 binds ACAD11. 8 / 8
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"Mechanistically, USP38 directly interacts with ACAD11 and deubiquitinates it, resulting in abnormal fatty acid oxidation."
40460554
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"In our study, we found that the USP38-ACAD11 axis mediated fatty acids metabolism disorder is linked to the AGE-RAGE signaling pathway through lipidomic analysis and RNA sequencing analysis."
40460554
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"Our findings reveal a novel pathogenesis for DCM and suggest that targeting the USP38-ACAD11 axis may provide a potential therapeutic strategy to improve mitochondrial energy metabolism in DCM."
40460554
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"As expected, the endogenous binding of USP38 and ACAD11 was confirmed in NRCMs with antibodies against USP38 and ACAD11 ( xref D and E)."
40460554
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"Likewise, the exogenous binding of USP38 and ACAD11 was verified in HEK293T cells transfected with plasmid encoding USP38 and ACAD11 ( xref F and G)."
40460554
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"Based on these findings, we performed Co-immunoprecipitation (Co-IP) to confirm the interaction between USP38 and ACAD11."
40460554
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"USP38 interacts with ACAD11 to modulate ACAD11 activity."
40460554
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"Taken together, these findings indicate that USP38 specifically interacts with ACAD11 to reduce its K63-linked polyubiquitination."
40460554