IndraLab

Statements

OTUB2 activates U2AF2. 3 / 3
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"OTUB2 increases the activity of the glycolytic enzyme PGK1 and activates Akt/mTOR signalling pathways to promote the Warburg effect in NSCLC by stabilising U2AF2 [49] ."
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"Taken together, these results indicate that OTUB2 promotes xenograft tumor growth of NSCLC cells by stabilizing U2AF2 and enhancing the Warburg effect In vivo."
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"Consistently, OTUB2 overexpression in XL-2 and H292 cells increased the half-life of U2AF2 protein in the presence of CHX."
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