IndraLab

Statements

USP13 increases the amount of extracellular matrix. 5 / 5
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"The results indicate that USP13 promotes ECM expression by stabilizing Smad4 in lung fibroblasts and plays a role in the maintenance of the extracellular matrix in lungs."
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"The reductions in both protein levels and mRNA expression of ECM were observed in the isolated lung fibroblasts from USP13 deficient mice, suggesting that downregulation of USP13 reduces ECM levels through inhibiting its transcription."
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"In summary, USP13 is a positive regulator of Smad4 stability and promotes ECM expression in lung fibroblast cells."
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"In this study, we identify that USP13 promotes ECM expression by stabilizing Smad4 in lung fibroblast cells."
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"To investigate the molecular mechanisms by which USP13 modulates ECM expression, we focused on the role of USP13 on Smad4 expression."
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