IndraLab

Statements

Troglitazone inhibits FOS. 3 / 3
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"Troglitazone (1 microM), a member of the thiazolidinedione class, produced a near complete inhibition of both bFGF induced DNA synthesis as measured by bromodeoxyuridine incorporation (6.5 +/-3.9 vs. 17.6 +/-4.3% cells labeled, P < 0.05) and c-fos induction."
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"Inhibition of c-fos induction by troglitazone appeared to occur via a blockade of the MAP kinase pathway at a point downstream of MAP kinase activation by MAP kinase kinase."
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"Further, troglitazone also activates ERK1/2 [XREF_BIBR] and blocks c-fos synthesis [XREF_BIBR] which could also modulate these effects."
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