IndraLab

Statements

SIRT6 activates USP10. 10 / 10
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"These findings present evidence that Sirt6 mediates the effect of USP10 in the regulation of CH in response to Ang II stimulation."
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"32 These findings present evidence that Sirt6 mediates the effect of USP10 in the regulation of CH in response to Ang II stimulation."
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"Our study has presented evidence that Sirt6 mediates the effect of USP10 in the regulation of CH in response to Ang II stimulation."
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"Ang II induced cardiac hypertrophy potentiated by USP10 knockdown was also completely blocked by Sirt6 activity upregulation."
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"Furthermore, USP10 physically binds to sirtuin 6 (Sirt6) and Sirt6 mediates the effect of USP10 on the regulation of CH."
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"These findings demonstrated that the Sirt6 mediated the effect of USP10 in regulation of CH in response to Ang II stimulation."
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"Knockdown of Sirt6 abrogates USP10 overexpression-mediated effects."
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"To further prove the principle that USP10 suppresses c-Myc transcriptional activity through both SIRT6 and p53, we tested whether knockdown of SIRT6 rescues this USP10 suppressive activity."
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"We have previously reported that KSHV infection decreased SIRT6 expression by blocking SIRT6’s interaction with ubiquitin-specific peptidase 10, leading to its degradation via a ubiquitin–proteasome pathway (36)."
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"Sirt6 Mediates USP10 Regulated Cardiac Hypertrophy."
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